COORDINATED MOLECULAR CROSS-TALK BETWEEN STAPHYLOCOCCUS AUREUS, ENDOTHELIAL CELLS AND PLATELETS IN BLOODSTREAM INFECTION

Coordinated Molecular Cross-Talk between Staphylococcus aureus, Endothelial Cells and Platelets in Bloodstream Infection

Staphylococcus aureus is an opportunistic pathogen often carried asymptomatically on the human body.Upon entry to the otherwise sterile environment of the cardiovascular system, S.aureus can lead to serious complications resulting in organ failure and death.The success of S.aureus as a pathogen in the bloodstream is due to its ability to express a

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Apocynin, a Selective NADPH Oxidase (Nox2) Inhibitor, Ameliorates Behavioural and Learning Deficits in the Fragile X Syndrome Mouse Model

Background/Objectives: Fragile X Syndrome (FXS) is associated with intellectual disability, hyperactivity, social anxiety and signs of autism.Hyperactivation of NADPH oxidase has been previously described in the brain of the male Fmr1-KO mouse.This work aims to demonstrate the efficacy of Apocynin, a specific NADPH oxidase inhibitor, in treating Fr

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